Date Name Title Filing Type Shares Traded Price Total Held
Dec 19, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Other acquisition or disposition -- -- 10,414
Dec 19, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Other acquisition or disposition -- -- 2,798
Dec 17, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 4,562 -- 4,562
Dec 17, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 25,438 -- 25,438
Nov 20, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Bona fide gift 34,684 -- 34,684
Dec 18, 2006
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 4,966 -- 4,966
Dec 18, 2006
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 25,034 -- 25,034
Nov 17, 2006
VP, Regulatory Development
VP, Regulatory Development Form 4 Bona fide gift 8,352 -- 12,803
Dec 19, 2005
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 16,463 -- 16,463
Dec 19, 2005
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 13,537 -- 13,537

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.