Date Name Title Filing Type Shares Traded Price Total Held
May 25, 2018
EVP Research and Development
EVP Research and Development Form 4 Other acquisition or disposition -- -- 4,660
May 25, 2018
EVP Research and Development
EVP Research and Development Form 4 Other acquisition or disposition -- -- 2,317
May 25, 2018
EVP Research and Development
EVP Research and Development Form 4 Other acquisition or disposition -- -- 5,673
May 24, 2018
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 11,407 $295.09 31,973
May 23, 2018
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 26,736 $30.63 58,709
May 23, 2018
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 15,329 $293.68 43,380
May 23, 2018
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 26,736 -- --
Dec 12, 2017
EVP Research and Development
EVP Research and Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 50,000 -- 50,000
Jun 23, 2017
EVP Research and Development
EVP Research and Development Form 4 Other acquisition or disposition -- -- 10,000
Jun 23, 2017
EVP Research and Development
EVP Research and Development Form 4 Other acquisition or disposition -- -- 5,000

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.