Date Name Title Filing Type Shares Traded Price Total Held
Jun 01, 2017
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 1,068 $464.98 24,797
Jun 01, 2017
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 6,017 $145.70 30,814
Jun 01, 2017
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 1,885 $464.98 28,929
Jun 01, 2017
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 2,167 $464.98 26,762
Jun 01, 2017
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 6,017 -- --
Jun 01, 2017
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 4,527 -- --
Dec 20, 2016
EVP Research and Development
EVP Research and Development Form 4 Other acquisition or disposition -- -- 10,000
Dec 20, 2016
EVP Research and Development
EVP Research and Development Form 4 Other acquisition or disposition -- -- 5,000
Dec 20, 2016
EVP Research and Development
EVP Research and Development Form 4 Other acquisition or disposition -- -- 5,621
Dec 16, 2016
EVP Research and Development
EVP Research and Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 58,342 -- 58,342

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.