Date Name Title Filing Type Shares Traded Price Total Held
Nov 05, 2015
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 75,000 $30.63 97,029
Nov 05, 2015
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 4,047 $567.63 92,982
Nov 05, 2015
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 39,605 $567.63 53,377
Nov 05, 2015
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,000 $21.25 78,377
Nov 05, 2015
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 935 $567.63 77,442
Nov 05, 2015
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 13,312 $567.63 64,130
Nov 05, 2015
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,000 -- 20,295
Nov 05, 2015
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 75,000 -- 46,736
May 28, 2015
EVP Research and Development
EVP Research and Development Form 4 Bona fide gift 1,000 -- 16,405
Dec 18, 2014
SVP Research and Development S
SVP Research and Development S Form 4 Other acquisition or disposition -- -- 20,000

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.