Date Name Title Filing Type Shares Traded Price Total Held
Aug 02, 2021
Director
Director Form 4 Open market or private sale of non-derivative or derivative security 28 $578.67 23,433
Aug 02, 2021
Director
Director Form 4 Open market or private sale of non-derivative or derivative security 39 $579.35 23,394
Aug 02, 2021
Director
Director Form 4 Open market or private sale of non-derivative or derivative security 3 $580.33 23,391
Aug 04, 2021
EVP Commercial
EVP Commercial Form 4 Other acquisition or disposition -- -- 116
Aug 05, 2021
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 2,559 $391.92 3,450
Aug 05, 2021
Director
Director Form 4 Open market or private sale of non-derivative or derivative security 2,559 $600.00 891
Aug 05, 2021
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 2,559 -- 5,118
Aug 05, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 50,000 $600.06 937,483
Aug 06, 2021
EVP Finance CFO
EVP Finance CFO Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 2,000 $381.92 27,903
Aug 06, 2021
EVP Finance CFO
EVP Finance CFO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 1,636 $607.51 26,267

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.