Date Name Title Filing Type Shares Traded Price Total Held
Jun 21, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 8,099 $540.61 34,809
Jun 21, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 19,911 $541.44 14,898
Jun 21, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 10,514 $542.43 4,384
Jun 21, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 2,276 $543.13 2,108
Jun 23, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 987,483
Jun 23, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 5,845
Jun 23, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 211,585
Jun 24, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Bona fide gift 211,585 -- 213,693
Jun 24, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Bona fide gift 211,585 -- --
Jun 25, 2021
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 2,084 $371.40 2,975

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.