Collaboration Agreement [Abstract] Collaboration Agreement Schedule of Research and Development Arrangement, Contract to Perform for Others [Table] Schedule of Research and Development Arrangement, Contract to Perform for Others [Table] Subsequent Event Type [Axis] Subsequent Event Type [Axis] Subsequent Event Type [Domain] Subsequent Event Type [Domain] Subsequent Event [Member] Subsequent Event [Member] Scenario [Axis] Scenario [Axis] Scenario, Unspecified [Domain] Scenario, Unspecified [Domain] Scenario, Forecast [Member] Scenario, Forecast [Member] Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Research and Development Arrangement, Contract to Perform for Others, Type [Domain] Research and Development Arrangement, Contract to Perform for Others, Type [Domain] Praluent, sarilumab, and dupilumab [Member] Praluent, sarilumab, and dupilumab [Member] Praluent, sarilumab, and dupilumab [Member] Type of Arrangement and Non-arrangement Transactions [Axis] Type of Arrangement and Non-arrangement Transactions [Axis] Arrangements and Non-arrangement Transactions [Domain] Arrangements and Non-arrangement Transactions [Domain] Range [Axis] Range [Axis] Range [Domain] Range [Domain] Minimum [Member] Minimum [Member] Maximum [Member] Maximum [Member] Research and Development Arrangement Contract to Perform for Others by Product [Axis] Research and Development Arrangement Contract to Perform for Others by Product [Axis] Research and Development Arrangement Contract to Perform for Others by Product [Axis] Research and Development Arrangement Contract to Perform for Others by Product [Domain] Research and Development Arrangement Contract to Perform for Others by Product [Domain] [Domain] for Research and Development Arrangement Contract to Perform for Others by Product [Axis] Antibody Collaboration Antibody Collaboration [Member] In November 2007, the Company entered into a global, strategic collaboration (the Antibody Collaboration) with Sanofi to discover, develop, and commercialize fully human monoclonal antibodies. IO Discovery Agreement IO Discovery Agreement [Member] In July 2015, the Company entered into a collaboration agreement (Immuno-Oncology agreement) with Sanofi, to jointly develop and commercialize Immuno-Oncology programs. IO Agreement IO Agreement [Member] IO Agreement Immuno-oncology Agreement Immuno-oncology Agreement [Member] Immuno-oncology Agreement Products and Services [Axis] Products and Services [Axis] Products and Services [Domain] Products and Services [Domain] Collaboration Agreement [Line Items] Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Accounts Receivable, Net, Current Accounts Receivable, Net, Current Percentage of repayment of development balance out of profits Percentage of development cost for the territory outside the United States previously required to be paid for under the collaboration Percentage of development cost for the territory outside the United States previously required to be paid for under the collaboration. Net profit (loss) from commercialization of products under collaboration agreement Net profit (loss) from commercialization of products under collaboration agreement Our share of profits/losses related to commercialization of products by our collaborator based on sales outside the United States. Under the terms of our collaboration agreement, we share profits/losses with our collaborator on commercialization of products. Recognition of Deferred Revenue Recognition of Deferred Revenue Annual funding maximum of research activities per amended agreement Annual funding maximum of research activities per amended agreement The maximum annual amount of funding for research activities through 2017 per the amended agreement. License agreement term License agreement term Potential agreement term, from the effective date of agreement. Reimbursement of Regeneron research and development expenses Research and Development Arrangement, Contract to Perform for Others, Compensation Earned Reimbursement Revenue Reimbursement Revenue Contracts Revenue Contracts Revenue Revenue from Related Parties Revenue from Related Parties Percentage of Trial Costs borne by collaborating party Percentage of Trial Costs borne by collaborating party The percentage of subsequent Shared Phase 3 Trial costs borne by the collaborating party upon receipt of the first positive Phase 3 trial results for a co-developed drug candidate. Percentage of Trial Costs borne by entity Percentage of Trial Costs borne by entity The percentage of subsequent Shared Phase 3 Trial costs borne by the Company upon receipt of the first positive Phase 3 trial results for a co-developed drug candidate. Research and development Research and Development Expense Annual Funding Maximum of Research Activities Per Agreement Annual Funding Maximum of Research Activities Per Agreement The maximum amount of cost reimbursement the Company will receive on a annual basis. Deferred Revenue, Additions Deferred Revenue, Additions Deferred Revenue From Related Party Current Deferred Revenue From Related Party Current The current portion of deferred revenue from related parties as of balance sheet date. Current deferred revenue is a liability related to a revenue producing activity for which revenue has not yet been recognized, and is expected to be recognized in the next twelve months. Generally, an entity records deferred revenue when it receives consideration before achieving certain criteria that must be met for revenue to be recognized in conformity with GAAP. Income Tax Disclosure [Abstract] Income Taxes Income Tax Disclosure [Text Block] Revenues [Abstract] Product Sales and Concentration Risk [Text Block] Product Sales and Concentration Risk [Text Block] Product Sales and Concentration Risk Disclosure [Text Block] Earnings Per Share [Abstract] Net Income Per Share Earnings Per Share [Text Block] Collaboration Agreement with Bayer Collaboration Agreement with Bayer HealthCare LLC [Member] Collaboration agreement with Bayer HealthCare LLC. Revenue based on percentage of annual sales in Japan Revenue based on percentage of annual sales in Japan The percentage on annual sales in Japan that the Company is entitled to receive, subject to certain potential adjustments. Payables and Accruals [Abstract] Accounts Payable and Accrued Liabilities, Current [Abstract] Accounts payable Accounts Payable, Trade, Current Accrued payroll and related costs Employee-related Liabilities, Current Accrued clinical trial expense Accrued Clinical Trial Expense Current Carrying value as of the balance sheet date of obligations incurred (and for which invoices have not been received) in connection with clinical trials. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Accrued sales-related charges, deductions and royalties Accrued sales-related charges, deductions and royalties Carrying value as of the balance sheet date of sales-related charges, deductions and obligations incurred through that date and accrual for royalties. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Taxes Payable, Current Taxes Payable, Current Other accrued expenses and liabilities Other Accrued Liabilities, Current Accounts payable and accrued expenses Accounts Payable and Accrued Liabilities, Current Fair Value Disclosures [Abstract] Fair Value Measurements Fair Value Disclosures [Text Block] Schedules of Concentration of Risk, by Risk Factor [Table Text Block] Schedules of Concentration of Risk, by Risk Factor [Table Text Block] Sales Related Deductions Activity Schedule of Sales Related Deductions Activity [Table Text Block] Tabular disclosure of the activity of sales-related deductions during the period, which may include rebates and chargebacks, and distributor-related fees. New Accounting Pronouncements and Changes in Accounting Principles [Abstract] Description of New Accounting Pronouncements Not yet Adopted [Text Block] Description of New Accounting Pronouncements Not yet Adopted [Text Block] Statement of Cash Flows [Abstract] Statement [Table] Statement [Table] Statement [Line Items] Statement [Line Items] Cash flows from operating activities: Net Cash Provided by (Used in) Operating Activities [Abstract] Net income Net Income (Loss) Attributable to Parent Adjustments to reconcile net income to net cash provided by operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Depreciation and amortization Depreciation, Depletion and Amortization Non-cash compensation expense Share-based Compensation Other non-cash charges and expenses, net Other Noncash Income (Expense) Deferred taxes Increase (Decrease) in Deferred Income Taxes Changes in assets and liabilites Increase (Decrease) in Operating Capital [Abstract] Increase in Sanofi, Bayer, and trade accounts receivable Increase (Decrease) in Accounts Receivable Increase in Inventories Increase (Decrease) in Inventories (Increase) decrease in prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets Increase in deferred revenue Increase (Decrease) in Deferred Revenue Increase in accounts payable, accrued expenses and other liabilities Increase (Decrease) in Accounts Payable and Accrued Liabilities Total adjustments Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities Net cash provided by operating activities Net Cash Provided by (Used in) Operating Activities Cash flows from investing activities: Net Cash Provided by (Used in) Investing Activities [Abstract] Purchases of marketable securities Payments to Acquire Marketable Securities Sales or maturities of marketable securities Proceeds from Sale and Maturity of Marketable Securities Capital expenditures Payments to Acquire Productive Assets Net cash used in investing activities Net Cash Provided by (Used in) Investing Activities Cash flows from financing activities: Net Cash Provided by (Used in) Financing Activities [Abstract] Proceeds in connection with capital and facility lease obligations Proceeds from (Repayments of) Long-term Debt and Capital Securities Payments in connection with capital and facility lease obligations Repayments of Long-term Debt Repayments of convertible senior notes Repayments of Convertible Debt Payments in connection with deduction of outstanding warrants Payments for Repurchase of Warrants Proceeds from issuance of Common Stock Proceeds from Issuance of Common Stock Payments in connection with Common Stock tendered for employee tax obligations Payments Related to Tax Withholding for Share-based Compensation Net cash provided by (used in) financing activities Net Cash Provided by (Used in) Financing Activities Net increase (decrease) in cash and cash equivalents Cash and Cash Equivalents, Period Increase (Decrease) Cash and cash equivalents at beginning of period Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents at end of period Revenue Recognition, Revenue Reductions [Policy Text Block] Revenue Recognition, Revenue Reductions [Policy Text Block] Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Equity Components [Axis] Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Additional Paid-in Capital [Member] Additional Paid-in Capital [Member] Class of Warrant or Right [Axis] Class of Warrant or Right [Axis] Class of Warrant or Right [Domain] Class of Warrant or Right [Domain] Income Statement Location [Axis] Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Accrued capital expenditures Accrued Capital Expenditures Carrying value as of the balance sheet date of obligations incurred and payable for purchases of fixed assets. Included in accounts payable and accrued expenses. Capital Lease Obligations Incurred Capital Lease Obligations Incurred Marketable Securities, Unrealized Gain (Loss) Marketable Securities, Unrealized Gain (Loss) Statement of Comprehensive Income [Abstract] Income Statement [Abstract] Income Statement [Abstract] Revenues: Net product sales Sales Revenue, Goods, Net Sanofi collaboration revenue Bayer Collaboration Revenue Other Collaboration Revenue Revenue realized from sharing of profits/losses on commercialized products, reimbursement of research and development expenses, and other transactions with our collaborator Bayer during the period. Other revenue Other Revenue, Net Total revenues Revenues Expenses: Costs and Expenses [Abstract] Selling, general, and administrative Selling, General and Administrative Expense Cost of goods sold Cost of Goods Sold Cost of collaboration and contract manufacturing Cost of manufacturing Total cost related to third-party royalties the Company is obligated to pay based on sales of commercial product by the Company’s collaborators, as well as costs in connection with producing commercial supplies for the Company’s collaborators and others. Total expenses Costs and Expenses Income from operations Operating Income (Loss) Other income (expense): Nonoperating Income (Expense) [Abstract] Other income (expense), net Other Nonoperating Income (Expense) Interest expense Interest Income (Expense), Nonoperating, Net Total other income (expense) Nonoperating Income (Expense) Income before income taxes Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest Income tax expense Income Tax Expense (Benefit) Net income per share - basic Earnings Per Share, Basic Net income per share - diluted Earnings Per Share, Diluted Weighted average shares outstanding - basic Weighted Average Number of Shares Outstanding, Basic Weighted average shares outstanding - diluted Weighted Average Number of Shares Outstanding, Diluted Statements of Comprehensive Income Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] Other comprehensive income (loss): Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Unrealized gain (loss) on marketable securities, net of tax Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Comprehensive income Comprehensive Income (Loss), Net of Tax, Attributable to Parent Document And Entity Information [Abstract] -- None. No documentation exists for this element. -- Entities [Table] Class of Stock [Axis] Class of Stock [Domain] Common Stock Common Stock [Member] Class A Stock Common Class A [Member] Entity Information [Line Items] Entity Registrant Name Entity Registrant Name Entity Central Index Key Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Filer Category Entity Filer Category Document Type Document Type Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Amendment Flag Amendment Flag Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Basic and Diluted Net Income (Loss) Per Share Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Antidilutive Securities Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Statement of Financial Position [Abstract] Class A Stock Common Stock ASSETS Assets [Abstract] Current assets: Assets, Current [Abstract] Cash and cash equivalents Marketable securities Marketable Securities, Current Accounts receivable - trade, net Accounts Receivable from Sanofi Accounts Receivable, Related Parties, Current Accounts receivable from Bayer Accounts and Notes Receivable, Net Inventories Inventory, Net Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Total current assets Assets, Current Marketable securities Marketable Securities, Noncurrent Property, plant, and equipment, net Property, Plant and Equipment, Net Deferred tax assets Deferred Tax Assets, Net, Noncurrent Other assets Other Assets, Noncurrent Total assets Assets LIABILITIES and STOCKHOLDERS' EQUITY Liabilities and Equity [Abstract] Current liabilities: Liabilities, Current [Abstract] Accounts payable and accrued expenses Capital and facility lease obligations, current Capital and facility lease obligations, current Amount of capital and facility lease obligation due within one year or the normal operating cycle, if longer. Deferred revenue from Sanofi, current portion Deferred Revenue, Current Deferred Revenue, Current Other current liabilities Other Liabilities, Current Total current liabilities Liabilities, Current Deferred revenue from Sanofi Deferred Revenue From Related Party Noncurrent The noncurrent portion of deferred revenue from related parties as of balance sheet date. Noncurrent deferred revenue is a liability related to a revenue producing activity for which revenue has not yet been recognized, and is not expected to be recognized in the next twelve months. Generally, an entity records deferred revenue when it receives consideration from a customer before achieving certain criteria that must be met for revenue to be recognized in conformity with GAAP. Deferred Revenue, Noncurrent Deferred Revenue, Noncurrent Capital and facility lease obligations Capital and facility lease obligations, noncurrent Represents the noncurrent portion of a lease liability Other long-term liabilities Other Liabilities, Noncurrent Total liabilities Liabilities Stockholders' equity: Stockholders' Equity Attributable to Parent [Abstract] Preferred Stock Preferred Stock, Value, Issued Common stock Common Stock, Value, Issued Additional paid-in capital Additional Paid in Capital Retained earnings Retained Earnings (Accumulated Deficit) Accumulated other comprehensive income Accumulated Other Comprehensive Income (Loss), Net of Tax Treasury stock Treasury Stock, Value Total stockholders' equity Stockholders' Equity Attributable to Parent Total liabilities and stockholders' equity Liabilities and Equity Organization, Consolidation and Presentation of Financial Statements [Abstract] Interim Financial Statements Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] New Accounting Pronouncement, Early Adoption [Table] New Accounting Pronouncement, Early Adoption [Table] New Accounting Pronouncement, Early Adoption [Axis] New Accounting Pronouncement, Early Adoption [Axis] New Accounting Principles, Early Adoption [Domain] New Accounting Principles, Early Adoption [Domain] New Accounting Pronouncement, Early Adoption, Effect [Member] New Accounting Pronouncement, Early Adoption, Effect [Member] Adjustments for New Accounting Pronouncements [Axis] Adjustments for New Accounting Pronouncements [Axis] Adjustment for new accounting pronouncements [Domain] Type of Adoption [Domain] Accounting Standards Update 2016-09 [Member] Accounting Standards Update 2016-09 [Member] Accounting Standards Update 2016-09 [Member] New Accounting Pronouncement, Early Adoption [Line Items] New Accounting Pronouncement, Early Adoption [Line Items] Excess Tax Benefit from Share-based Compensation, Financing Activities Excess Tax Benefit from Share-based Compensation, Financing Activities Dilutive Securities, Effect on Basic Earnings Per Share New Accounting Pronouncement or Change in Accounting Principle, Effect of Change on Diluted Earnings Per Share Interest on Convertible Debt, Net of Tax Interest on Convertible Debt, Net of Tax Net Income (Loss) Available to Common Stockholders, Diluted Net Income (Loss) Available to Common Stockholders, Diluted Effect of dilutive securities: Dilutive Securities, Effect on Basic Earnings Per Share [Abstract] Weighted Average Number of Shares Outstanding Reconciliation [Abstract] Weighted Average Number of Shares Outstanding Reconciliation [Abstract] Effect of dilutive securities (in shares): Incremental Weighted Average Shares Attributable to Dilutive Effect [Abstract] Stock options Incremental Common Shares Attributable to Dilutive Effect of Share-based Payment Arrangements Restricted stock Incremental Common Shares Attributable To Nonvested Restricted Shares Nonvested equity-based payment awards that result in incremental common shares. Incremental Common Shares Attributable to Dilutive Effect of Conversion of Debt Securities Incremental Common Shares Attributable to Dilutive Effect of Conversion of Debt Securities Warrants Incremental Common Shares Attributable to Dilutive Effect of Call Options and Warrants Dilutive potential shares Weighted Average Number Diluted Shares Outstanding Adjustment Weighted average shares - diluted (in shares) Earnings Per Share, Basic and Diluted [Abstract] Net income per share - diluted (in dollars per share) Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Stock options Employee Stock Option [Member] Restricted Stock [Member] Restricted Stock [Member] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Weighted average number of shares Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Collaboration revenue with related party Schedule of Related Party Transactions [Table Text Block] Collaboration revenue Collaboration revenue [Table Text Block] Summary of collaboration revenue [Table Text Block] Statement of Cash Flows Cash Flow, Supplemental Disclosures [Text Block] PDGFR-beta outside the US [Member] PDGFR-beta outside the US [Member] PDGFR-beta outside the US Percentage of global development cost to be paid by the collaboration partner under the collaboration Percentage of global development cost to be paid by the collaboration partner under the collaboration Percentage of global development cost to be paid by the collaboration partner under the collaboration Percentage of development cost for the territory outside the United States to be paid for under the collaboration Deferred Revenue, Additions Collaboration Agreements [Abstract] Collaboration Agreements [Abstract] Project [Axis] Project [Axis] Project [Domain] Project [Domain] Research and Development Arrangement, Contract to Perform for Others [Line Items] Research and Development Arrangement, Contract to Perform for Others [Line Items] Accounts Payable and Accrued Expenses Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Investments, Debt and Equity Securities [Abstract] Schedule of Available-for-sale Securities [Table] Classification of Investment [Axis] Classification of Investment [Axis] This element represents the general categories of investments, which may be classified as Unrestricted or Restricted. Classification of Investment [Domain] Classification of Investment [Domain] Provides general categories of investments for which information is required or determined to be disclosed. Unrestricted [Member] Unrestricted [Member] Investments whose use is not restricted in whole or in part, by contractual agreements or regulatory requirements. Major Types of Debt and Equity Securities [Axis] Major Types of Debt and Equity Securities [Domain] Corporate Bond Securities [Member] Corporate Bond Securities [Member] U.S. government and government agency obligations US Treasury and Government [Member] Municipal bonds Municipal Bonds [Member] Commercial Paper [Member] Commercial Paper [Member] Certificates of Deposit [Member] Certificates of Deposit [Member] Equity Securities Equity Securities [Member] Schedule of Available-for-sale Securities [Line Items] Marketable Securities, Realized Gain (Loss) Marketable Securities, Realized Gain (Loss) Realized Gain (Loss) on Marketable Securities and Cost Method Investments, Excluding Other than Temporary Impairments, and Other Investments Realized Gain (Loss) on Marketable Securities and Cost Method Investments, Excluding Other than Temporary Impairments, and Other Investments Amortized Cost Basis Available-for-sale Securities, Amortized Cost Basis Available-for-sale Securities, Accumulated Gross Unrealized Gain, before Tax Available-for-sale Securities, Accumulated Gross Unrealized Gain, before Tax Available-for-sale Securities, Accumulated Gross Unrealized Loss, before Tax Available-for-sale Securities, Accumulated Gross Unrealized Loss, before Tax Available-for-sale Securities Available-for-sale Securities Available-for-sale Securities, Debt Maturities, Fair Value [Abstract] Available-for-sale Securities, Debt Maturities, Fair Value, Fiscal Year Maturity [Abstract] Maturities within one year Available-for-sale Securities, Debt Maturities, Next Twelve Months, Fair Value Maturities after one year through five years Available-for-sale Securities, Debt Maturities, Year Two Through Five, Fair Value Available-for-sale Securities, Debt Maturities, Year Six Through Ten, Fair Value Available-for-sale Securities, Debt Maturities, Year Six Through Ten, Fair Value Total Available-for-sale Securities, Debt Securities Continuous Unrealized Loss Position, Fair Value [Abstract] Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value [Abstract] Fair Value - Less than 12 Months Available-for-sale Securities, Continuous Unrealized Loss Position, Less than Twelve Months, Fair Value Fair Value - 12 Months or Greater Available-for-sale Securities, Continuous Unrealized Loss Position, Twelve Months or Longer, Fair Value Fair Value - Total Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value Continuous Unrealized Loss Position, Aggregate Losses [Abstract] Available-for-sale Securities, Continuous Unrealized Loss Position, Aggregate Loss [Abstract] Unrealized Loss - Less than 12 months Available-for-sale Securities, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss Unrealized Loss - 12 Months or Greater Available-for-sale Securities, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss Unrealized Loss - Total Available-for-sale Securities, Continuous Unrealized Loss Position, Accumulated Loss Realized Gain (Loss) on Marketable Securities, Cost Method Investments, and Other Investments Other Comprehensive Income (Loss), Reclassification Adjustment from AOCI for Sale of Securities, before Tax Realized Gain (Loss) on Marketable Securities, Cost Method Investments, and Other Investments Realized Gain (Loss) on Marketable Securities, Cost Method Investments, and Other Investments Revenue Disclosure [Table] Revenue Disclosure [Table] Besse Medical [Member] Besse Medical [Member] Besse Medical [Member] EYLEA EYLEA Net Product Sales [Member] Revenue during the period derived from a specified product line (EYLEA), after deducting applicable provisions for discounts, returns, rebates, chargebacks, distribution fees, and other sales-related deductions. ARCALYST Arcalyst Net Product Sales [Member] Revenue during the period derived from a specified product line (ARCALYST), after deducting applicable provisions for discounts, returns, rebates, chargebacks, distribution fees, and other sales-related deductions. McKesson Corporation [Member] McKesson Corporation [Member] McKesson Corporation [Member] Curascript SD [Member] Curascript SD [Member] Curascript SD [Member] Concentration Risk Type [Axis] Concentration Risk Type [Domain] Customer concentration risk Customer Concentration Risk [Member] Concentration Risk by Benchmark [Axis] Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Gross Sales Revenue GrossSalesRevenue [Member] GrossSalesRevenue [Member] Valuation Allowances and Reserves Type [Axis] Valuation Allowances and Reserves Type [Axis] Valuation Allowances and Reserves [Domain] Valuation Allowances and Reserves [Domain] Rebates and Chargebacks Rebates and Chargebacks [Member] A valuation allowance for rebates and chargebacks under governmental programs (including Medicaid), which are netted against revenue from product sales. Distribution Related Fees Distribution Related Fees [Member] A valuation allowance for distribution-related fees which are netted against revenue from product sales. Other Sales Related Deductions Other Sales Related Deductions [Member] A valuation allowance for other sales-related deductions which are netted against revenue from product sales. Revenue Disclosure [Line Items] Revenues from External Customers and Long-Lived Assets [Line Items] Risks and Uncertainties [Abstract] Risks and Uncertainties [Abstract] Concentration risk, percentage Concentration Risk, Percentage Activity of Sales Related Deductions [Roll Forward] Movement in Valuation Allowances and Reserves [Roll Forward] Balance Valuation Allowances and Reserves, Balance Provision related to current period sales Valuation Allowances and Reserves, Charged to Other Accounts Credits/payments Valuation Allowances and Reserves, Deductions Marketable Securities Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Inventory Disclosure [Abstract] Inventory Write-down Inventory Write-down Raw materials Inventory, Raw Materials, Net of Reserves Work in process Inventory, Work in Process, Net of Reserves Finished goods Inventory, Finished Goods, Net of Reserves Deferred costs Other Inventory, Net of Reserves Total Inventories Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Preferred stock, shares issued (in shares) Preferred Stock, Shares Issued Preferred stock, shares outstanding (in shares) Preferred Stock, Shares Outstanding Common Stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Common Stock, shares authorized (in shares) Common Stock, Shares Authorized Common Stock, shares issued (in shares) Common Stock, Shares, Issued Common Stock, shares outstanding (in shares) Common Stock, Shares, Outstanding Treasury Stock, shares outstanding (in shares) Treasury Stock, Shares Leases disclosure [Abstract] Leases disclosure [Abstract] Leases of Lessee Disclosure [Text Block] Leases of Lessee Disclosure [Text Block] Legal Matters [Abstract] Legal Matters [Abstract] Loss Contingencies [Table] Loss Contingencies [Table] Balance Sheet Location [Axis] Balance Sheet Location [Axis] Balance Sheet Location [Domain] Balance Sheet Location [Domain] Litigation Case [Axis] Litigation Case [Axis] Litigation Case [Domain] Litigation Case [Domain] Litigation Status [Axis] Litigation Status [Axis] Litigation Status [Domain] Litigation Status [Domain] Loss Contingency Nature [Axis] Loss Contingency Nature [Axis] Loss Contingency, Nature [Domain] Loss Contingency, Nature [Domain] Loss Contingencies [Line Items] Loss Contingencies [Line Items] Loss Contingency, Damages Sought, per unit produced. Loss Contingency, Damages Sought, per unit produced. Loss Contingency, Damages Sought, per unit produced. Loss Contingency, Damages Sought, Value Loss Contingency, Damages Sought, Value Debt Disclosure [Abstract] Debt Disclosure [Text Block] Debt Disclosure [Text Block] Schedule of Capital Leased Assets [Table] Schedule of Capital Leased Assets [Table] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Type [Domain] Capital Leased Assets [Line Items] Capital Leased Assets [Line Items] Facility Purchase Price Facility Purchase Price Agreed to purchase price for entire Tarrytown, New York facility, subject to certain customary adjustments. Payment towards purchase price of Tarrytown facility Payment towards purchase price of Tarrytown facility Payment towards purchase price of Tarrytown facility. A proportionate amount of which was recorded as a reduction of capital and facility lease obligations. Aggregate funding advanced to the participants Aggregate funding advanced by the participants Aggregate funding advanced by the participants, and used by Banc of America Leasing and Capital to acquire the Tarrytown facility. Payment towards purchase price Reimbursement received by the Company Reimbursement received by the Company upon closing of the purchase agreement. Initial term of lease Initial term of lease Initial term of lease Potential extended term of lease Potential extended term of lease Potential extended term of lease Tarrytown facility capital and facility Lease obligations Tarrytown facility capital and facility lease obligations Capital and facility lease obligations recorded by the Company related to the Tarrytown facility. Schedule of Inventory, Current Schedule of Inventory, Current [Table Text Block] Collaboration Agreements Collaborative Arrangement Disclosure [Text Block] November 2015 Warrant Agreement November 2015 Agreement [Member] November 2015 Agreement [Member] February 2016 Warrant Agreement February 2016 Agreement [Member] February 2016 Agreement [Member] Long-term Debt, Type [Axis] Long-term Debt, Type [Axis] Long-term Debt, Type [Domain] Long-term Debt, Type [Domain] Credit Facility [Domain] Credit Facility [Domain] Convertible senior notes Convertible Debt [Member] Scenario [Axis] Debt Conversion Debt Conversion The principal amount of convertible notes that were settled for previously surrendered conversions. Stock Issued During Period, Shares, New Issues Stock Issued During Period, Shares, New Issues Adjustments to Additional Paid in Capital, Equity Component of Convertible Debt, Subsequent Adjustments Adjustments to Additional Paid in Capital, Equity Component of Convertible Debt, Subsequent Adjustments Treasury Stock, Shares Treasury Stock, Value Limit price per share for warrant holders to close out hedge position Limit price per share for warrant holders to close out hedge position Limit price per share for warrant holders to close out hedge position pursuant to the agreement. Payments in connection with deduction of outstanding warrants Reduction of number of warrants Reduction of number of warrants Reduction of number of warrants Line of Credit Facility, Maximum Borrowing Capacity Line of Credit Facility, Maximum Borrowing Capacity Line of Credit Facility, Expiration Period Line of Credit Facility, Expiration Period Line of Credit Facility, Fair Value of Amount Outstanding Line of Credit Facility, Fair Value of Amount Outstanding Ang2 Antibody [Member] Ang2 Antibody [Member] Ang2 Antibody [Member] Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Counterparty Name [Axis] Counterparty Name [Axis] Counterparty Name [Domain] Counterparty Name [Domain] Mitsubishi Tanabe Pharma Corporation (MTPC) Mitsubishi Tanabe Pharma Corporation (MTPC) [Member] Mitsubishi Tanabe Pharma Corporation (MTPC) [Member] Collaborative Arrangement Collaborative Arrangement [Member] Payment [Axis] Payment [Axis] Payment [Axis] Payment [Domain] Payment [Domain] [Domain] for Payment [Axis] First Payment [Member] First Payment [Member] First Payment [Member] Second Payment [Member] Second Payment [Member] Second Payment [Member] Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Operating Loss Carryforwards [Table] Operating Loss Carryforwards [Table] Income Tax Authority [Axis] Income Tax Authority [Axis] Income Tax Authority [Domain] Income Tax Authority [Domain] Geographical [Axis] Geographical [Axis] Geographical [Domain] Geographical [Domain] Operating Loss Carryforwards [Line Items] Operating Loss Carryforwards [Line Items] Total income tax expense (benefit) Effective income tax rate Effective Income Tax Rate Reconciliation, Percent Available-for-sale Securities, Income Tax Expense on Change in Unrealized Holding Gain (Loss) Available-for-sale Securities, Income Tax Expense on Change in Unrealized Holding Gain (Loss) Schedule of Accounts Payable and Accrued Liabilities Schedule of Accounts Payable and Accrued Liabilities [Table Text Block] EYLEA PDGFR-beta Other Collaboration Revenue Commitments and Contingencies Disclosure [Abstract] Legal Matters Legal Matters and Contingencies [Text Block] Schedule of assets measured at fair value on a recurring basis Fair Value, Assets Measured on Recurring and Nonrecurring Basis [Table Text Block] Teva Pharmaceuticals [Member] Teva Pharmaceuticals [Member] Teva Pharmaceuticals Collaboration Agreement Collaborative Arrangement [Member] Revenues Fair Value Measurements, Recurring and Nonrecurring [Table] Mitsubishi Tanabe Pharma Corporation (MTPC) [Member] Measurement Basis [Axis] Measurement Basis [Axis] Fair Value Measurement [Domain] Fair Value Measurement [Domain] Portion at Fair Value Measurement [Member] Portion at Fair Value Measurement [Member] Estimate of Fair Value Measurement [Member] Estimate of Fair Value Measurement [Member] Measurement Frequency [Axis] Fair Value, Measurement Frequency [Domain] Measured on a recurring basis Fair Value, Measurements, Recurring [Member] Fair Value, Hierarchy [Axis] Fair Value Hierarchy [Domain] Quoted Prices in Active Markets for Identical Assets (Level 1) Fair Value, Inputs, Level 1 [Member] Significant Other Observable Inputs (Level 2) Fair Value, Inputs, Level 2 [Member] Fair Value, Inputs, Level 3 [Member] Fair Value, Inputs, Level 3 [Member] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets, Level 1 to Level 2 Transfers, Amount Fair Value, Assets, Level 1 to Level 2 Transfers, Amount Proceeds from Sale and Maturity of Marketable Securities Other than Temporary Impairment Losses, Investments Other than Temporary Impairment Losses, Investments Payments to Acquire Marketable Securities Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Transfers Into Level 3 Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Transfers Into Level 3 Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers out of Level 3 Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers out of Level 3 Available-for-sale marketable securities: Available-for-sale Securities [Abstract] U.S. government and government agency obligations U S Government Obligations Fair Value Disclosure This element represents the portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. This item represents available-for-sale securities which consist of investments in U.S. government and government agency obligations neither classified as trading or held-to-maturity securities. Corporate bonds Financial Instruments, Owned, Corporate Debt, at Fair Value Municipal bonds Municipal Debt Securities, at Carrying Value Commercial Paper Commercial Paper Certificates of Deposit, at Carrying Value Certificates of Deposit, at Carrying Value Equity securities Available-for-sale Securities, Equity Securities Total fair value of available-for-sale marketable securities Available-for-sale Securities Available-for-sale Securities [Table Text Block] Marketable Securities, Based on Contractual Maturity Dates Investments Classified by Contractual Maturity Date [Table Text Block] Fair Value and Unrealized Losses of Marketable Securities Schedule of Unrealized Loss on Investments [Table Text Block] Legal Costs, Policy [Policy Text Block] Legal Costs, Policy [Policy Text Block] Inventory Inventory Disclosure [Text Block]