<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:0b1d2b9d-13e2-477f-894a-0c1a354ccba2,g:5ca10141-cdfc-4951-a11b-ede08bbcadad-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.regeneron.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUnaudited" xlink:type="simple" xlink:href="regn-20230630.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSUnaudited"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_a5de9eb1-9824-47be-afe0-12cf582f12d8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_80b763ec-d4db-4414-92e6-e25845081711" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a5de9eb1-9824-47be-afe0-12cf582f12d8" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_80b763ec-d4db-4414-92e6-e25845081711" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_6367eb1e-9849-474c-a6c0-e82cc29809ed" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a5de9eb1-9824-47be-afe0-12cf582f12d8" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_6367eb1e-9849-474c-a6c0-e82cc29809ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_35b1ce19-9cab-4755-9bc5-aeb45675f802" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a5de9eb1-9824-47be-afe0-12cf582f12d8" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_35b1ce19-9cab-4755-9bc5-aeb45675f802" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_9e3bb149-7ecf-4d5c-b510-a2fb97464a4c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a5de9eb1-9824-47be-afe0-12cf582f12d8" xlink:to="loc_us-gaap_InventoryNet_9e3bb149-7ecf-4d5c-b510-a2fb97464a4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_fe2e7121-3d04-4259-85e3-8db19358171a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_a5de9eb1-9824-47be-afe0-12cf582f12d8" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_fe2e7121-3d04-4259-85e3-8db19358171a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_f944b488-105d-48b3-bf33-f918786f781b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_9c1302ad-c5a3-4012-b8cb-128dd40b6970" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_f944b488-105d-48b3-bf33-f918786f781b" xlink:to="loc_us-gaap_LiabilitiesCurrent_9c1302ad-c5a3-4012-b8cb-128dd40b6970" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_71a267b7-bb79-4655-9f9f-dcb3f59d65de" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_f944b488-105d-48b3-bf33-f918786f781b" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_71a267b7-bb79-4655-9f9f-dcb3f59d65de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_5f1b15d4-b5ab-4ccb-b8f5-fc93259cdc00" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_f944b488-105d-48b3-bf33-f918786f781b" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_5f1b15d4-b5ab-4ccb-b8f5-fc93259cdc00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_bf50c4ed-d81a-4206-8415-0e9901c0ba45" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_f944b488-105d-48b3-bf33-f918786f781b" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_bf50c4ed-d81a-4206-8415-0e9901c0ba45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_6ba83b75-afbc-460b-af02-0de82242d180" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_f944b488-105d-48b3-bf33-f918786f781b" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_6ba83b75-afbc-460b-af02-0de82242d180" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_38965efa-e682-4f10-98f1-5fc54f45b661" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_5be27029-b2dc-4f03-91f6-d2e2451d8d3e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_38965efa-e682-4f10-98f1-5fc54f45b661" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_5be27029-b2dc-4f03-91f6-d2e2451d8d3e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_6959deae-a468-47bb-a7f1-5627c501b3f3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_38965efa-e682-4f10-98f1-5fc54f45b661" xlink:to="loc_us-gaap_AssetsCurrent_6959deae-a468-47bb-a7f1-5627c501b3f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesNoncurrent_ab655245-c076-434c-8824-e7898788e72e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MarketableSecuritiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_38965efa-e682-4f10-98f1-5fc54f45b661" xlink:to="loc_us-gaap_MarketableSecuritiesNoncurrent_ab655245-c076-434c-8824-e7898788e72e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_117f1f76-cc34-4905-9252-6d054053b932" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_38965efa-e682-4f10-98f1-5fc54f45b661" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_117f1f76-cc34-4905-9252-6d054053b932" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_c3bfc437-656e-4ffd-a2c1-63a14e42137e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_38965efa-e682-4f10-98f1-5fc54f45b661" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_c3bfc437-656e-4ffd-a2c1-63a14e42137e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_ea17f260-5435-4144-afd4-823d909b8477" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_38965efa-e682-4f10-98f1-5fc54f45b661" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_ea17f260-5435-4144-afd4-823d909b8477" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_f1006c82-803a-431d-acf2-362afe519f8d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_2e76ccf3-b1ad-48b8-b0b5-025fa75567af" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_f1006c82-803a-431d-acf2-362afe519f8d" xlink:to="loc_us-gaap_Liabilities_2e76ccf3-b1ad-48b8-b0b5-025fa75567af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_3577ca2c-69bd-480b-a143-1526b044696f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_f1006c82-803a-431d-acf2-362afe519f8d" xlink:to="loc_us-gaap_StockholdersEquity_3577ca2c-69bd-480b-a143-1526b044696f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_c60d8f90-52ff-47e1-966e-0f948bc3880f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_20027bc6-f209-43c8-9560-18df5985ba2a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c60d8f90-52ff-47e1-966e-0f948bc3880f" xlink:to="loc_us-gaap_CommonStockValue_20027bc6-f209-43c8-9560-18df5985ba2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_407bc085-df15-4c2b-a2c8-2b96a17d4424" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c60d8f90-52ff-47e1-966e-0f948bc3880f" xlink:to="loc_us-gaap_TreasuryStockCommonValue_407bc085-df15-4c2b-a2c8-2b96a17d4424" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_df1edbe7-db8a-4b72-b323-58fa07e0df2e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c60d8f90-52ff-47e1-966e-0f948bc3880f" xlink:to="loc_us-gaap_AdditionalPaidInCapital_df1edbe7-db8a-4b72-b323-58fa07e0df2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_dd54d0d9-e5a2-4b3a-abf2-42567ce5309e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c60d8f90-52ff-47e1-966e-0f948bc3880f" xlink:to="loc_us-gaap_PreferredStockValue_dd54d0d9-e5a2-4b3a-abf2-42567ce5309e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_7413bcac-459d-4da8-96f8-345e8591407b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c60d8f90-52ff-47e1-966e-0f948bc3880f" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_7413bcac-459d-4da8-96f8-345e8591407b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_586a034a-bb7d-4dc9-8f51-ad3a95c83d9c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c60d8f90-52ff-47e1-966e-0f948bc3880f" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_586a034a-bb7d-4dc9-8f51-ad3a95c83d9c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_7d8d617e-845f-423e-9939-d0c83d2d982e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_70cc1465-010d-48b7-9455-6a89fc086c6d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_7d8d617e-845f-423e-9939-d0c83d2d982e" xlink:to="loc_us-gaap_AccountsPayableCurrent_70cc1465-010d-48b7-9455-6a89fc086c6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_dc25571a-b0f6-42eb-93df-9c6e99719da0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedLiabilitiesAndOtherLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_7d8d617e-845f-423e-9939-d0c83d2d982e" xlink:to="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_dc25571a-b0f6-42eb-93df-9c6e99719da0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_24b1bce2-ded1-4b6d-afa1-5d0c4973c678" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_7d8d617e-845f-423e-9939-d0c83d2d982e" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_24b1bce2-ded1-4b6d-afa1-5d0c4973c678" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMEUnaudited" xlink:type="simple" xlink:href="regn-20230630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMEUnaudited"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMEUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_d2ffdbc2-a6b6-43f5-a57d-98fcc154caeb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_a7143771-3973-486f-a75a-5d3c56f75993" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_d2ffdbc2-a6b6-43f5-a57d-98fcc154caeb" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_a7143771-3973-486f-a75a-5d3c56f75993" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_06a283ce-a09e-4922-bb78-84a0e8392a98" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_d2ffdbc2-a6b6-43f5-a57d-98fcc154caeb" xlink:to="loc_us-gaap_InterestExpense_06a283ce-a09e-4922-bb78-84a0e8392a98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_a7a1aa0b-8f80-4642-a86f-630f2f420e2f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_909b6fbb-365e-489a-9e2d-a733ba78d833" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_a7a1aa0b-8f80-4642-a86f-630f2f420e2f" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_909b6fbb-365e-489a-9e2d-a733ba78d833" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_a69b57c5-dee2-4b44-8705-14d5cc1dd203" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_a7a1aa0b-8f80-4642-a86f-630f2f420e2f" xlink:to="loc_us-gaap_CostsAndExpenses_a69b57c5-dee2-4b44-8705-14d5cc1dd203" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_6489d901-b05a-40c6-b6c3-a23f29abcabb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseNet_7fa204d0-f52f-47e9-936b-1a474d4be0b3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherOperatingIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_6489d901-b05a-40c6-b6c3-a23f29abcabb" xlink:to="loc_us-gaap_OtherOperatingIncomeExpenseNet_7fa204d0-f52f-47e9-936b-1a474d4be0b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_6000b2b2-d747-44f1-9492-3d93eccfa0f5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_6489d901-b05a-40c6-b6c3-a23f29abcabb" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_6000b2b2-d747-44f1-9492-3d93eccfa0f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_AcquiredInProcessResearchAndDevelopment_0e7a30e2-1648-4441-bf39-e6c5bd410c1c" xlink:href="regn-20230630.xsd#regn_AcquiredInProcessResearchAndDevelopment"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_6489d901-b05a-40c6-b6c3-a23f29abcabb" xlink:to="loc_regn_AcquiredInProcessResearchAndDevelopment_0e7a30e2-1648-4441-bf39-e6c5bd410c1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_12bddc55-48b7-4a74-a194-1c65b8c1670b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_6489d901-b05a-40c6-b6c3-a23f29abcabb" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_12bddc55-48b7-4a74-a194-1c65b8c1670b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_e83fb739-9e1e-4624-b3c0-ccea118afe7e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_6489d901-b05a-40c6-b6c3-a23f29abcabb" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_e83fb739-9e1e-4624-b3c0-ccea118afe7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_916de0de-7afb-4488-a489-7aa637f1f0ec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_9c7d026c-4390-4ee2-ba38-b075a0e5743f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_916de0de-7afb-4488-a489-7aa637f1f0ec" xlink:to="loc_us-gaap_NetIncomeLoss_9c7d026c-4390-4ee2-ba38-b075a0e5743f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_cb900314-812f-48fd-a944-6bf2bb335193" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_916de0de-7afb-4488-a489-7aa637f1f0ec" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_cb900314-812f-48fd-a944-6bf2bb335193" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_e8cdc5d6-b2f1-41c7-a38a-ce948b0b5c9b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_916de0de-7afb-4488-a489-7aa637f1f0ec" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_e8cdc5d6-b2f1-41c7-a38a-ce948b0b5c9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_3fcdea32-499c-43de-ae0c-d250f1f93deb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_916de0de-7afb-4488-a489-7aa637f1f0ec" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_3fcdea32-499c-43de-ae0c-d250f1f93deb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_a424363c-e5c0-4004-8126-c154736a9cb3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_e20e8fd6-af07-430f-ae63-775bebc35d9b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_a424363c-e5c0-4004-8126-c154736a9cb3" xlink:to="loc_us-gaap_OperatingIncomeLoss_e20e8fd6-af07-430f-ae63-775bebc35d9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_f98ca1b2-a140-41ba-8f59-898251b86466" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_a424363c-e5c0-4004-8126-c154736a9cb3" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_f98ca1b2-a140-41ba-8f59-898251b86466" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_44d50b14-5a3f-46c1-8fbc-816d0c966cc8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_7fb20331-d222-4afa-8c90-618e5646335e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_44d50b14-5a3f-46c1-8fbc-816d0c966cc8" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_7fb20331-d222-4afa-8c90-618e5646335e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_024c018e-850a-456c-8962-8da8470a9b71" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_44d50b14-5a3f-46c1-8fbc-816d0c966cc8" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_024c018e-850a-456c-8962-8da8470a9b71" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="simple" xlink:href="regn-20230630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_a3a456ed-4535-4c31-98f7-3c5ecea9696e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0f2f85ed-24e6-44d7-9f3c-715d635b2495" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_a3a456ed-4535-4c31-98f7-3c5ecea9696e" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0f2f85ed-24e6-44d7-9f3c-715d635b2495" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ae019c02-5c11-497a-84f4-63641c578386" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_a3a456ed-4535-4c31-98f7-3c5ecea9696e" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ae019c02-5c11-497a-84f4-63641c578386" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_d11e02ff-8556-4fb2-a202-9e7e52a2a87a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_a3a456ed-4535-4c31-98f7-3c5ecea9696e" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_d11e02ff-8556-4fb2-a202-9e7e52a2a87a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_d8bd842e-32ee-40dc-b407-4d2fb0babd34" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_a3a456ed-4535-4c31-98f7-3c5ecea9696e" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_d8bd842e-32ee-40dc-b407-4d2fb0babd34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fd877069-d0d1-40bd-8a7b-b59ae3c24615" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_0d9a498d-f6b9-48b5-aa61-c90506810143" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fd877069-d0d1-40bd-8a7b-b59ae3c24615" xlink:to="loc_us-gaap_NetIncomeLoss_0d9a498d-f6b9-48b5-aa61-c90506810143" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_fcb2bbc4-d429-4bbb-bbeb-ef4385d89f38" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fd877069-d0d1-40bd-8a7b-b59ae3c24615" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_fcb2bbc4-d429-4bbb-bbeb-ef4385d89f38" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_d63a33cb-a9bc-4645-9d0b-365cf4ddfd06" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_7f6cf09b-064e-4376-89c9-01d3507203c5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_d63a33cb-a9bc-4645-9d0b-365cf4ddfd06" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_7f6cf09b-064e-4376-89c9-01d3507203c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_d3832ec6-8bd7-4213-aeee-6ae2f3ff943e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_d63a33cb-a9bc-4645-9d0b-365cf4ddfd06" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_d3832ec6-8bd7-4213-aeee-6ae2f3ff943e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_6781be93-3dfb-431f-bea7-ea9f5d4ca6f1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_d63a33cb-a9bc-4645-9d0b-365cf4ddfd06" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_6781be93-3dfb-431f-bea7-ea9f5d4ca6f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_aea6690f-708b-4a30-bf6d-4503af5e4efa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_d63a33cb-a9bc-4645-9d0b-365cf4ddfd06" xlink:to="loc_us-gaap_ShareBasedCompensation_aea6690f-708b-4a30-bf6d-4503af5e4efa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_af13468d-789e-4672-9215-7cf50aaf6f11" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_d63a33cb-a9bc-4645-9d0b-365cf4ddfd06" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_af13468d-789e-4672-9215-7cf50aaf6f11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_256f22e5-7a39-45cb-a0cb-bf3d07f15b66" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_d63a33cb-a9bc-4645-9d0b-365cf4ddfd06" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_256f22e5-7a39-45cb-a0cb-bf3d07f15b66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_501cab26-2366-48e9-a022-df7f72b2be54" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_d63a33cb-a9bc-4645-9d0b-365cf4ddfd06" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_501cab26-2366-48e9-a022-df7f72b2be54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_MarketableAndOtherSecuritiesGainLoss_c310fec4-00fd-4117-bb02-2670cbb3fe07" xlink:href="regn-20230630.xsd#regn_MarketableAndOtherSecuritiesGainLoss"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_d63a33cb-a9bc-4645-9d0b-365cf4ddfd06" xlink:to="loc_regn_MarketableAndOtherSecuritiesGainLoss_c310fec4-00fd-4117-bb02-2670cbb3fe07" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_f080e1a3-ef81-437e-9473-ebcb4a90f85a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_d63a33cb-a9bc-4645-9d0b-365cf4ddfd06" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_f080e1a3-ef81-437e-9473-ebcb4a90f85a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_3b070ef0-9c82-4e25-95fc-500f1672d264" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_d63a33cb-a9bc-4645-9d0b-365cf4ddfd06" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_3b070ef0-9c82-4e25-95fc-500f1672d264" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_AcquiredInProcessResearchAndDevelopmentAssetAcquisition_5406006e-4695-4d89-a1f0-f43055d5f976" xlink:href="regn-20230630.xsd#regn_AcquiredInProcessResearchAndDevelopmentAssetAcquisition"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_d63a33cb-a9bc-4645-9d0b-365cf4ddfd06" xlink:to="loc_regn_AcquiredInProcessResearchAndDevelopmentAssetAcquisition_5406006e-4695-4d89-a1f0-f43055d5f976" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5ac7dd2e-3c50-4cb9-a4f1-83625217ce3a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_PaymentsForAssetAcquisition_0e1cac5d-48ce-43a2-a3c7-50ac3a0b9626" xlink:href="regn-20230630.xsd#regn_PaymentsForAssetAcquisition"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5ac7dd2e-3c50-4cb9-a4f1-83625217ce3a" xlink:to="loc_regn_PaymentsForAssetAcquisition_0e1cac5d-48ce-43a2-a3c7-50ac3a0b9626" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_638d54d3-5a47-4864-84a6-99b2df613d4e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireProductiveAssets"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5ac7dd2e-3c50-4cb9-a4f1-83625217ce3a" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_638d54d3-5a47-4864-84a6-99b2df613d4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_PaymentsToAcquireIntangibleAssets1_d14cfed8-dacf-41b6-a320-508a60e5aba2" xlink:href="regn-20230630.xsd#regn_PaymentsToAcquireIntangibleAssets1"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5ac7dd2e-3c50-4cb9-a4f1-83625217ce3a" xlink:to="loc_regn_PaymentsToAcquireIntangibleAssets1_d14cfed8-dacf-41b6-a320-508a60e5aba2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_3243713d-716b-4901-bd4c-eb49a4a0419f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5ac7dd2e-3c50-4cb9-a4f1-83625217ce3a" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_3243713d-716b-4901-bd4c-eb49a4a0419f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_03fff7eb-294f-404a-a775-f68360e7d15d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5ac7dd2e-3c50-4cb9-a4f1-83625217ce3a" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_03fff7eb-294f-404a-a775-f68360e7d15d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_fe71e343-0e06-4830-bd4b-d62c1115d13c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_023b525a-c5eb-46d6-8d66-363cadcb5c9c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_fe71e343-0e06-4830-bd4b-d62c1115d13c" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_023b525a-c5eb-46d6-8d66-363cadcb5c9c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_bc30aa17-3a99-43de-8100-daa9c31f261d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_fe71e343-0e06-4830-bd4b-d62c1115d13c" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_bc30aa17-3a99-43de-8100-daa9c31f261d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_8d07409e-e329-46ad-86a0-2eb4b0a18122" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_fe71e343-0e06-4830-bd4b-d62c1115d13c" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_8d07409e-e329-46ad-86a0-2eb4b0a18122" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/NetIncomePerShareScheduleofBasicandDilutedNetIncomePerShareDetails" xlink:type="simple" xlink:href="regn-20230630.xsd#NetIncomePerShareScheduleofBasicandDilutedNetIncomePerShareDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/NetIncomePerShareScheduleofBasicandDilutedNetIncomePerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_2f4659e0-f332-4776-81f7-6766d59a38b8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_79844971-e145-4726-95e2-a447dc88aa1c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_2f4659e0-f332-4776-81f7-6766d59a38b8" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_79844971-e145-4726-95e2-a447dc88aa1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_e57270e5-6dc0-41c7-b1a1-e958c52139e3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_2f4659e0-f332-4776-81f7-6766d59a38b8" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_e57270e5-6dc0-41c7-b1a1-e958c52139e3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/MarketableSecuritiesScheduleofInvestmentsinAvailableForSaleDebtSecuritiesDetails" xlink:type="simple" xlink:href="regn-20230630.xsd#MarketableSecuritiesScheduleofInvestmentsinAvailableForSaleDebtSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/MarketableSecuritiesScheduleofInvestmentsinAvailableForSaleDebtSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_34fb39a6-9e77-4245-8761-f95efc8acb31" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3e459b48-ba9c-431e-9338-30c5819ff30c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_34fb39a6-9e77-4245-8761-f95efc8acb31" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3e459b48-ba9c-431e-9338-30c5819ff30c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_db5b15b1-0447-4be4-aad7-a41f5d478e57" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_34fb39a6-9e77-4245-8761-f95efc8acb31" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_db5b15b1-0447-4be4-aad7-a41f5d478e57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_576fd6d3-a9cb-4070-9f89-92ed14a3c652" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_34fb39a6-9e77-4245-8761-f95efc8acb31" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_576fd6d3-a9cb-4070-9f89-92ed14a3c652" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/MarketableSecuritiesScheduleofDebtSecuritiesBasedonContractualMaturityDatesDetails" xlink:type="simple" xlink:href="regn-20230630.xsd#MarketableSecuritiesScheduleofDebtSecuritiesBasedonContractualMaturityDatesDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/MarketableSecuritiesScheduleofDebtSecuritiesBasedonContractualMaturityDatesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_772092b1-e4a4-484a-b18f-f857b4b852c8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_0eed2e74-93a7-46b3-8707-6e7ac349b88d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_772092b1-e4a4-484a-b18f-f857b4b852c8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_0eed2e74-93a7-46b3-8707-6e7ac349b88d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_5587b58c-0796-43ef-834d-eebaf35b475c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_772092b1-e4a4-484a-b18f-f857b4b852c8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_5587b58c-0796-43ef-834d-eebaf35b475c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYear5_ee1664b4-df03-4c6e-9743-a3946d4a31e9" xlink:href="regn-20230630.xsd#regn_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYear5"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_772092b1-e4a4-484a-b18f-f857b4b852c8" xlink:to="loc_regn_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYear5_ee1664b4-df03-4c6e-9743-a3946d4a31e9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/MarketableSecuritiesScheduleofFairValueandUnrealizedLossesofDebtSecuritiesDetails" xlink:type="simple" xlink:href="regn-20230630.xsd#MarketableSecuritiesScheduleofFairValueandUnrealizedLossesofDebtSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/MarketableSecuritiesScheduleofFairValueandUnrealizedLossesofDebtSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_c789e228-bdd7-43b2-9cf2-0111dd69d168" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_dfb94160-682e-4277-b512-16f888936989" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_c789e228-bdd7-43b2-9cf2-0111dd69d168" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_dfb94160-682e-4277-b512-16f888936989" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_fc7f0cdc-7884-464a-b0f6-717d2355d213" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_c789e228-bdd7-43b2-9cf2-0111dd69d168" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_fc7f0cdc-7884-464a-b0f6-717d2355d213" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_6a5707e0-1f6e-467b-80cc-e8083c14aed9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_b902aa5a-b38c-4ac0-b27c-9192e245dbce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_6a5707e0-1f6e-467b-80cc-e8083c14aed9" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_b902aa5a-b38c-4ac0-b27c-9192e245dbce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_e7b29d4c-da04-4a3a-8145-1bf1387a1228" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_6a5707e0-1f6e-467b-80cc-e8083c14aed9" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_e7b29d4c-da04-4a3a-8145-1bf1387a1228" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/FairValueMeasurementsScheduleofAssetsMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="regn-20230630.xsd#FairValueMeasurementsScheduleofAssetsMeasuredatFairValueonaRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/FairValueMeasurementsScheduleofAssetsMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_d1c4f53b-b505-4641-b63d-73c10bf7dff9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_932cd8f9-afd8-4c94-b366-4ec6cee70eba" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_d1c4f53b-b505-4641-b63d-73c10bf7dff9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_932cd8f9-afd8-4c94-b366-4ec6cee70eba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_b64f781f-d148-4ec8-a71f-e9657d95b571" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_d1c4f53b-b505-4641-b63d-73c10bf7dff9" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_b64f781f-d148-4ec8-a71f-e9657d95b571" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_8b29b560-78d0-4d91-88f6-b96fd867c3f3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_d1c4f53b-b505-4641-b63d-73c10bf7dff9" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_8b29b560-78d0-4d91-88f6-b96fd867c3f3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/InventoriesScheduleofInventoriesDetails" xlink:type="simple" xlink:href="regn-20230630.xsd#InventoriesScheduleofInventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/InventoriesScheduleofInventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_ee3d405c-8022-474d-b51c-cfebfeec693b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_5f179b46-2ab7-4fca-9ee6-059a42414504" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ee3d405c-8022-474d-b51c-cfebfeec693b" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_5f179b46-2ab7-4fca-9ee6-059a42414504" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_1639f0a7-bb13-48d5-912d-68f0f9299178" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ee3d405c-8022-474d-b51c-cfebfeec693b" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_1639f0a7-bb13-48d5-912d-68f0f9299178" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_fdb6ab7b-016e-4073-94ac-fbcab77dcfb0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ee3d405c-8022-474d-b51c-cfebfeec693b" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_fdb6ab7b-016e-4073-94ac-fbcab77dcfb0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherInventoryNetOfReserves_dfd671cd-978d-4388-a30e-cdaf410f2deb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherInventoryNetOfReserves"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ee3d405c-8022-474d-b51c-cfebfeec693b" xlink:to="loc_us-gaap_OtherInventoryNetOfReserves_dfd671cd-978d-4388-a30e-cdaf410f2deb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/CashFlowsScheduleofReconciliationofCashCashEquivalentsandRestrictedCashDetails" xlink:type="simple" xlink:href="regn-20230630.xsd#CashFlowsScheduleofReconciliationofCashCashEquivalentsandRestrictedCashDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/CashFlowsScheduleofReconciliationofCashCashEquivalentsandRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a7355b1b-a1e2-4364-aee0-3d2544565eee" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_6fb887d0-b569-4c23-88ec-72e4392455c3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a7355b1b-a1e2-4364-aee0-3d2544565eee" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_6fb887d0-b569-4c23-88ec-72e4392455c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_364759e7-bb7d-4208-aae9-331e2fdd2969" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a7355b1b-a1e2-4364-aee0-3d2544565eee" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_364759e7-bb7d-4208-aae9-331e2fdd2969" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_0c97d898-475c-4957-bc61-c6ac188daa66" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a7355b1b-a1e2-4364-aee0-3d2544565eee" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_0c97d898-475c-4957-bc61-c6ac188daa66" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
