0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 9952156 - Disclosure - Business Overview and Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - 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Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Long-Term Incentive Plans link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Employee Savings Plans link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Legal Matters link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Net Income Per Share link:presentationLink link:calculationLink link:definitionLink 9952173 - Disclosure - Statement of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Business Overview and Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Business Overview and Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Product Sales (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Collaboration, License, and Other Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Marketable Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Inventories (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Property, Plant, and Equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Intangible Assets (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Long-Term Incentive Plans (Tables) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Net Income Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Statement of Cash Flows (Tables) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Business Overview and Summary of Significant Accounting Policies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Business Overview and Summary of Significant Accounting Policies - Schedule of Significant Segment Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Business Overview and Summary of Significant Accounting Policies - Schedule of Estimated Useful Lives (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Product Sales - Schedule of Net Product Sales (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Product Sales - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Product Sales - Schedule of Concentration of Risk, by Risk Factor (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Product Sales - Schedule of Sales Related Deductions Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Collaboration, License, and Other Agreements - Schedule of Collaboration Revenue Earned From Sanofi (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Collaboration, License, and Other Agreements - Sanofi, Antibody Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Collaboration, License, and Other Agreements - Schedule of Accounts Receivable and Deferred Revenue Information, Antibody Collaboration (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Collaboration, License, and Other Agreements - Sanofi, Immuno-Oncology Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Collaboration, License, and Other Agreements - Bayer Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Collaboration, License, and Other Agreements - Schedule of Collaboration Revenue Earned From Bayer (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Collaboration, License, and Other Agreements - Schedule of Contract Balances, Bayer Collaborative (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Collaboration, License, and Other Agreements - Amounts Recognized in Statement of Operations with Roche (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Collaboration, License, and Other Agreements - Other Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Marketable Securities - Schedule of Investments in Available For Sale Debt Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Marketable Securities - Schedule of Debt Securities Based on Contractual Maturity Dates (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Marketable Securities - Schedule of Fair Value and Unrealized Losses of Debt Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Marketable Securities - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Fair Value Measurements - Schedule of Assets Measured at Fair Value on a Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Fair Value Measurements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Inventories - Schedule of Inventories (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Inventories - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Property, Plant, and Equipment - Schedule of Property, Plant, and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Property, Plant, and Equipment - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Intangible Assets - Schedule of Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - 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Leases - Other information related to finance lease (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Leases - Supplemental cash flows (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Leases - Analysis of lease liability maturities (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Leases - Analysis of lease liability maturities (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Stockholders' Equity - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955566 - Disclosure - Stockholders' Equity - Schedule of Repurchased Shares (Details) link:presentationLink link:calculationLink link:definitionLink 9955567 - Disclosure - Long-Term Incentive Plans - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955568 - Disclosure - Long-Term Incentive Plans - Summary of transactions involving stock option awards (Details) link:presentationLink link:calculationLink link:definitionLink 9955569 - Disclosure - Long-Term Incentive Plans - Summary of weighted-average exercise prices and weighted-average grant-date fair values of options issued (Details) link:presentationLink link:calculationLink link:definitionLink 9955570 - Disclosure - Long-Term Incentive Plans - Summary of weighted-average values of assumptions used in computing fair value of option grants (Details) link:presentationLink link:calculationLink link:definitionLink 9955571 - Disclosure - Long-Term Incentive Plans - Summary of activity related to restricted stock awards (Details) link:presentationLink link:calculationLink link:definitionLink 9955572 - Disclosure - Long-Term Incentive Plans - Summary of weighted-average values of assumptions used in computing fair value of performance-based options (Details) link:presentationLink link:calculationLink link:definitionLink 9955573 - Disclosure - Employee Savings Plans (Details) link:presentationLink link:calculationLink link:definitionLink 9955574 - Disclosure - Income Taxes - Schedule of income before income tax (Details) link:presentationLink link:calculationLink link:definitionLink 9955575 - Disclosure - Income Taxes - Schedule of components of income tax expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955576 - Disclosure - Income Taxes - Schedule of effective income tax rate reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 9955577 - Disclosure - Income Taxes - Schedule of deferred tax assets and liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955578 - Disclosure - Income Taxes - Schedule of unrecognized tax benefits (Details) link:presentationLink link:calculationLink link:definitionLink 9955579 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955580 - 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