| Date | Name | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| Mar 27, 2023 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Other acquisition or disposition | -- | -- | 569,653 |
| Mar 27, 2023 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Other acquisition or disposition | -- | -- | 5,869 |
| Mar 27, 2023 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Other acquisition or disposition | -- | -- | 200,000 |
| Mar 27, 2023 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Other acquisition or disposition | -- | -- | 250,000 |
| Mar 23, 2023 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Open market or private sale of non-derivative or derivative security | 254 | $800.59 | 200,250 |
| Mar 23, 2023 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Open market or private sale of non-derivative or derivative security | 122 | $801.16 | 200,128 |
| Mar 23, 2023 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Open market or private sale of non-derivative or derivative security | 1,237 | $802.54 | 198,891 |
| Mar 23, 2023 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Open market or private sale of non-derivative or derivative security | 642 | $803.30 | 198,249 |
| Mar 23, 2023 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Open market or private sale of non-derivative or derivative security | 254 | $804.38 | 197,995 |
| Mar 23, 2023 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Open market or private sale of non-derivative or derivative security | 47 | $805.55 | 197,948 |
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.