Insider Transactions

Date	Name	Title	Filing	Type	Shares Traded	Price	Total Held
Oct 15, 2026	MURPHY ANDREW J Co-Chief Scientific Officer Trans History: 294	Co-Chief Scientific Officer	Form 4	Other acquisition or disposition	--	--	4,414
Oct 14, 2026	MURPHY ANDREW J Co-Chief Scientific Officer Trans History: 294	Co-Chief Scientific Officer	Form 4	Open market or private sale of non-derivative or derivative security	6	$753.76	51,974
Oct 14, 2026	MURPHY ANDREW J Co-Chief Scientific Officer Trans History: 294	Co-Chief Scientific Officer	Form 4	Open market or private sale of non-derivative or derivative security	35	$755.91	51,939
Oct 14, 2026	MURPHY ANDREW J Co-Chief Scientific Officer Trans History: 294	Co-Chief Scientific Officer	Form 4	Open market or private sale of non-derivative or derivative security	16	$757.68	51,923
Oct 14, 2026	MURPHY ANDREW J Co-Chief Scientific Officer Trans History: 294	Co-Chief Scientific Officer	Form 4	Open market or private sale of non-derivative or derivative security	24	$758.16	51,899
Oct 14, 2026	MURPHY ANDREW J Co-Chief Scientific Officer Trans History: 294	Co-Chief Scientific Officer	Form 4	Open market or private sale of non-derivative or derivative security	14	$759.96	51,885
Oct 14, 2026	MURPHY ANDREW J Co-Chief Scientific Officer Trans History: 294	Co-Chief Scientific Officer	Form 4	Open market or private sale of non-derivative or derivative security	74	$760.65	51,811
Oct 14, 2026	MURPHY ANDREW J Co-Chief Scientific Officer Trans History: 294	Co-Chief Scientific Officer	Form 4	Open market or private sale of non-derivative or derivative security	27	$761.36	51,784
Oct 14, 2026	MURPHY ANDREW J Co-Chief Scientific Officer Trans History: 294	Co-Chief Scientific Officer	Form 4	Open market or private sale of non-derivative or derivative security	55	$762.57	51,729
Oct 14, 2026	MURPHY ANDREW J Co-Chief Scientific Officer Trans History: 294	Co-Chief Scientific Officer	Form 4	Open market or private sale of non-derivative or derivative security	25	$763.76	51,704

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.